I wouldn't be so happy about Cade's matchups. Against Tyson he was 5-18. Against Mobley he was 5-15. Not sure about Wade, apparently he didn't guard Cade much this year so maybe that's a better matchup this year even though it hadn't been in the past. Struss is a decent defender with size.
Hopefully JB will run screens to get some of the weaker defenders on Cade. Problem is that Mobley will be lurking and Cleveland's big men eat up Cade's drives. In order to prevent Mobley from roaming, they'll need to do what they did to Orlando and pull Ausar into the screening action. But Mobley isn't Suggs who Cade can dominate in the paint. You don't want that switch.
A smarter move might be to run off ball screens with Ausar and Duncan to force Cleveland to switch in order to prevent the open three. That will lock Mobley on a guy he can't leave. Now you're free to run your offense, pull Ausar into another screen to get Cade a mismatch, or whatever. Mobley can't leave the shooter or you make him pay.
Overall though I think Cade will need to have that three point shot and the middy rolling like he did in the last three games against Orlando otherwise it could be a long series for him (and us).
Your point about Harris being guarded by Harden is a good one. In general, the Pistons should do everything they can to target Harden on defense over and over the same way they'll try to target Duncan. He's decent at deflections but not much else on defense because he gives zero effort. He can't really guard anyone on the court.
You're point about Duren being stronger is a good one as well. I was surprised to see he actually had some really good games against Cleveland's front line this year. But so did Allen, going for 20+ in 2 out of 3 games. Mobley had some killers against us as well, averaging 18 pts, 8 rebounds, 4 assists, 3 blocks, and nearly 45% from three.