Lions receiver Amon-Ra St. Brown and offensive tackle Penei Sewell will face off with Bears receiver Equanimeous St. Brown and Bears rookie linebacker Noah Sewell. In the meantime pass rushers and brothers Romeo Okwara and Julian Okwara will also be active.
ESPN reported that in NFL history, there have been two games featuring three different sets of siblings. Both occurred in 1979 in games between the Pittsburgh Steelers and Cincinnati Bengals, which featured Matt and Chris Bahr, Jim and Ross Browner, and Archie and Ray Griffin, according to the Elias Sports Bureau.