A 7-seed has not beaten a 2-seed since the NFL expanded to 7 playoff teams, but I do think the Rams have the ability to knock a team off, wherever they land... Hopefully it's not the Lions. If the Rams beat the Giants and lose to the 49ers, while the Seahawks beat the Steelers and Cardinals, we'd be looking at an Eagles-Rams, Lions-Seahawks, and Cowboys-NFC South wildcard round. In which case a Rams victory would setup a divisional round game in Detroit, against the winner of Cowboys/NFC South.
The road to the 2-seed now would require both the Eagles and Cowboys losing out. Technically the 1-seed is in play too if both of them plus the 49ers lose out. If the Eagles beat the Cardinals and the 49ers beat the Commanders today (both overwhelmingly likely, but you never know), the Lions are locked into the 3-seed.