For the most part it hasn't affected friendships, but COVID made things rocky family wise, although I was lucky that (at least until last year) I was living pretty far away and it mostly manifested in phone calls.
The 2020 post election period, which happened in tangent with COVID, was an additional strain.... conversations would get steered in that direction and hearing about conspiracy theories about the TCF Center and Antrim County and whatnot (none of them made any sense) and I just didn't want to deal with it. I try my best to listen and reason and whatnot even in areas of disagreement, but when you can't even agree on basic facts, what's the point?
Overall, life is a lot better in my case as I've moved up in my career and make close to double what I made four years ago. Although I reckon that may not comport to everyone's experience.