We know that Walt and Jessie each have one more scene and they are separate scenes, but I think they are going let Jesse have the happy ending. He turned out to be a sympathetic character who actually had a soul, so he'll be the only one that doesn't get totally ruined.............He's been through his Hell.
If there is a spinoff, it would either be Kim in the post Gene timeline or maybe a younger Lalo (but not with Tony Dalton), but based on what I heard from a former co-worker from my ABQ radio days (he's a native), they're shutting down the studio there for good.