I see the likely end game as once everyone has had it or been immunized it will fade from significance as a public health crisis. As it morphs it will be dealt with using updated boosters and probably some kind of ongoing booster schedule will be developed. There will be some low background of uniquely sensitive individuals or those for whom vaccination doesn't work and it will always remain a risk for them, but as a mass public health issue those numbers will be low enough not to impact normalcy. Until we get there, those that continue to resist vaccination will get it and develop their resistance the hard way, or they will die.