Bill Shakin reads this forum, saw and recognized me at a ballgame, and semi stole my realignment ideas.
West: Dodgers, Angels, Padres, Giants, Athletics, Diamondbacks, Rockies, Mariners.
North: Tigers, White Sox, Cubs, Brewers, Twins, Reds, Guardians, Pirates.
South: Cardinals, Royals, Rangers, Astros, Marlins, Rays, Braves, Nashvilles.
East: Yankees, Mets, Red Sox, Phillies, Nationals, Orioles, Blue Jays, Expos.
I'd go further and do away with the AL/NL and just go with one MLB. The all star game teams can be handled some other way. The playoffs can be seeded by overall MLB standings.