I simulated this game myself in Madden 18. Good news is the Lions win. Stafford had 4 TDs and 1 INT that bounced off of Tate's hands in the end zone. Ebron and Abbrederis were the leading receivers with over 100 yards receiving each. Abdullah had a couple nice runs at the end to ice the game.
The defense was stout with Ansah and Hyder combining for multiple sacks. Still struggled against mobile QBs as Tyrod Taylor got a couple nice runs.
For the 1st time ever, I returned a kickoff for a TD as Johnson Bademosi went 102 yards for the TD.
Final score: Detroit 35, Buffalo 7
My prediction for this game based on the simulation: Lions 6, Bills 3.