I'd take those bubbles and double them up. 8 per division, 1 league. It'd be easier to start west and move eastward. If Salt Lake gets a team, just combine those two. If its Nashville and a more eastern team, say San Antonio or Charlotte as an example, then Colorado shifts over.
There's a way to realign that geographically that makes sense. Traditional AL and NL alignments might go out the window, but I'm fine with that. Maybe its a Central, Northeast and Southeast to go with the West. Or maybe its North, South, East, and West. Yankees, Mets, and Red Sox together. White Sox and Cubs and by extension Cardinals and Royals together. All of the western teams together to alleviate some of Seattle's traveling disadvantage. Pirates and Guardians and Reds together.