I suspect they will draft the best player available tonight, who fits their culture and has a first round grade on their board. If Holmes doesn't have 28 players with first round grades on his draft board then I think he is trading up for a player that is a BPA and his front office has given a first round grade. They are likely also not touching any player with character concerns, IE James Pearce Jr. or Mike Green. I like Mike Green quite a bit and feel he is the type of high motor, hard nose, physical, explosive, athletic pass rusher, who also plays against the run, that they might normally like. But I think Green's character concerns keep him off their board entirely.
I think it is wide open as far as the position they end up picking because they will heavily lean BPA with a first round grade over any sort of perceived team need. That could mean they go G/C with a guy like Gray Zabel or Tyler Booker. It could mean a DT or DE like Kenneth Grant, Derrick Harmon, Shemar Stewart, or Donovan Ezeiruaku. It could mean taking yet another first round LB like Jihaad Campbell or a CB like Will Johnson. It could even mean a complete surprise pick like Colston Loveland or Tyler Warren at TE or Matthew Golden or Emeka Egbuka at WR. I would not be shocked if they picked a player at a position outside the norm that we all expect them to draft (OG/C, DLine).
As far as who I want, I'd like them to draft in the trenches, either on offense or defense. I think there will be potentially a top talent available at either the offensive or defensive lines when they pick at #28. If they don't have a first round draft grade on the guy they probably aren't taking him. I would be ok with anyone Holmes drafts in the end because I trust him. However, I would prefer one of Derrick Harmon, Mike Green (I'm sure his character concerns will make him a no), Donovan Ezeiruaku, Mykel Williams, Gray Zabel or Tyler Booker.