Of course if he pitches on short rest, he may only be able to go 5 on Saturday (and it may not be normal Skubal) and we lose that game anyway.
Overall, I think they go 2 and 5 as his long term health is also a factor. They have been able to win with the matchups, I think they will trust that again. Reese is completely ready for Saturday as will be the entire pen. Trust the matchups Saturday, Let Skubal go Monday, hope to get 7+ out of him, and have a fresh staff for game 3 again on Wednesday.