I'd rather save him for game 2 just because if you can steal game 1, then you are in great shape to come home 2-0. If you don't, you are in great shape for a split on regular rest.
There wll be two off days before game 1, and 2 more between games 1 and 3 to rest the guys that go in game 1 and if Skubal has a good game then you only need a couple there.
But I see the logic in going 1-4 as well. If they win the series then whatever option they pick will be considerred genius.